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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594626Generated: October 31, 2026

Bromomethylcyclopropane → 1-(4-(Cyclopropylmethoxy)benzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

https://huagongshe.com/reaction/594626

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBromomethylcyclopropaneHCID 81503—
Reactant6-(2,6-Dimethoxyphenyl)-1-(4-hydroxybenzyl)piperidin-2-oneHCID 69081744—
Product1-(4-(Cyclopropylmethoxy)benzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-oneHCID 69084592—

Reaction Steps

Prepared according to the described general procedure 7 (GP7) by O-alkylation of 6-(2,6-dimethoxyphenyl)-1-(4-hydroxybenzyl)piperidin-2-one with commercially available (bromomethyl)cyclopropane. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.78 min.; [M+H]+: 396.27 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-b0158c0308974fbbb053e53e76029325
Source noteuspto-grants-2016_01