3-Chloro-1,2-propanediol → HCID 69081715, compound

HRID 594629Notes

Reaction equation

HRID 594629 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[CH:10]1[N:15]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=2)[C:14](=[O:28])[CH2:13][CH2:12][CH2:11]1.Cl[CH2:30][CH:31]([OH:34])[CH2:32][OH:33]>>[OH:34][CH:31]([CH2:32][OH:33])[CH2:30][O:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[CH:10]1[N:15]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:25])[F:26])=[CH:19][CH:18]=2)[C:14](=[O:28])[CH2:13][CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 72903-Chloro-1,2-propanediolHCID 69083694HCID 69083694, compound

Product 1

HCID 69081715HCID 69081715, compound

Procedure

Prepared according to the described general procedure 7 (GP7) by O-alkylation of 6-(2-hydroxy-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)piperidin-2-one with commercially available 3-chloropropane-1,2-diol. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.73 min.; [M+H]+: 470.28 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-d82ae7f44a23423ba44bf561af74fb44
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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