2-Methoxybenzaldehyde → HCID 69082267, compound

HRID 594634Notes

Reaction equation

HRID 594634 reaction equation
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH2:11])=[CH:6][CH:5]=1.[CH3:14][O:15][C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH:18]=O>>[CH3:14][O:15][C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH:18]1[N:11]([CH2:10][C:7]2[CH:6]=[CH:5][C:4]([O:3][C:2]([F:12])([F:13])[F:1])=[CH:9][CH:8]=2)[C:4](=[O:3])[CH2:5][CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 86582-MethoxybenzaldehydeHCID 5718464-(Trifluoromethoxy)benzylamine

Product 1

HCID 69082267HCID 69082267, compound

Procedure

Prepared according to the described general procedure 6 (GP6) with commercially available (4-(trifluoromethoxy)phenyl)methanamine and commercially available 2-methoxybenzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions H): tR=1.37 min.; [M+H]+: 379.75 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-98811bcfed224512b4a147f2ea925a12
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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