2,6-Dimethoxybenzaldehyde → 6-(2,6-dimethoxyphenyl)-1-((1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)methyl)piperidin-2-one

HRID 594639Notes

Reaction equation

HRID 594639 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][NH2:12])=[CH:10][C:5]=2[N:4]=[N:3]1.[CH3:13][O:14][C:15]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[C:16]=1[CH:17]=O>>[CH3:13][O:14][C:15]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[C:16]=1[CH:17]1[N:12]([CH2:11][C:9]2[CH:8]=[CH:7][C:6]3[N:2]([CH3:1])[N:3]=[N:4][C:5]=3[CH:10]=2)[C:15](=[O:14])[CH2:16][CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 964042,6-DimethoxybenzaldehydeHCID 2795420(1-Methyl-1H-1,2,3-Benzotriazol-5-Yl)Methylamine

Product 1

HCID 866956536-(2,6-dimethoxyphenyl)-1-((1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)methyl)piperidin-2-one

Procedure

Prepared according to the described general procedure 6 (GP6) with commercially available (1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)methanamine and commercially available 2,6-dimethoxybenzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.65 min.; [M+H]+: 381.09 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-b59890ace319484fa4eae81eebbfca35
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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