2-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → HCID 86695654, compound

HRID 594647Notes

Reaction equation

HRID 594647 reaction equation
P(OC1C=CC=CC=1)(OC1C=CC=CC=1)(O[C:4]1[N:5]([CH2:11][C:12]2[CH:17]=[CH:16][C:15](OC(F)(F)F)=[CH:14][CH:13]=2)[C:6](=[O:10])[CH2:7][CH2:8][CH:9]=1)=O.[F:37][C:38]([F:50])([F:49])[O:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=1B(O)O>>[F:37][C:38]([F:50])([F:49])[O:39][C:40]1[CH:45]=[CH:44][C:43]([CH2:4][N:5]2[CH:11]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[O:39][C:38]([F:50])([F:49])[F:37])[CH2:9][CH2:8][CH2:7][C:6]2=[O:10])=[CH:42][CH:41]=1

Participants

3

Reactant 2

HCID 27772042-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 69083750HCID 69083750, compound

Product 1

HCID 86695654HCID 86695654, compound

Procedure

Prepared according to the described general procedure 9 (GP9) with 6-oxo-1-(4-(trifluoromethoxy)benzyl)-1,4,5,6-tetrahydropyridin-2-yl diphenyl phosphate and commercially available (2-(trifluoromethoxy)phenyl)boronic acid. Subsequent hydrogenation and purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.83 min.; [M+H]+: 433.70 g/mol.

Workup

  1. customPrepared
  2. customSubsequent hydrogenation and purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-1a6271c61e5346e2aaa6bf7617018d9e
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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