HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethoxy)benzylamine → rac-(3R*,5S*)-5-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-3-hydroxy-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethoxy)benzylamine | HCID 571846 | — |
| Reactant | 2,3-Dihydro-1,4-benzodioxine-5-carbaldehyde | HCID 2795033 | — |
| Product | rac-(3R*,5S*)-5-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-3-hydroxy-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one | HCID 69085698 | — |
Reaction Steps
Prepared according to the described general procedures 10A2 (GP10A2), 10B (GP10B) and 10F (GP10F) using commercially available (4-(trifluoromethoxy)phenyl)methanamine and commercially available 2,3-dihydrobenzo[b][1,4]dioxine-5-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.79 min.; [M+H]+: 409.94 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-e80721e70d9647bda7fe8d68bf7c834d |
| Source note | uspto-grants-2016_01 |