3-(2-Methyl-1,3-thiazol-4-yl)benzaldehyde → 5-(2,4-Dimethoxypyridin-3-yl)-3-methyl-1-(3-(2-methylthiazol-4-yl)benzyl)pyrrolidin-2-one

Participants

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of methyl 4-amino-4-(2,4-dimethoxypyridin-3-yl)-2-methylbutanoate with commercially available 3-(2-methylthiazol-4-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.73 min.; [M+H]+: 424.03 g/mol.

Provenance & Evidence