HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Methylphenyl)-1,3-thiazole-4-carbaldehyde → 5-(2-Fluoro-6-methoxyphenyl)-3-methyl-1-((2-(p-tolyl)thiazol-4-yl)methyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Methylphenyl)-1,3-thiazole-4-carbaldehyde | HCID 14023571 | — |
| Reactant | Ethyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate | HCID 69085707 | — |
| Product | 5-(2-Fluoro-6-methoxyphenyl)-3-methyl-1-((2-(p-tolyl)thiazol-4-yl)methyl)pyrrolidin-2-one | HCID 69081676 | — |
Reaction Steps
Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate with commercially available 2-(p-tolyl)thiazole-4-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.94 min.; [M+H]+: 411.02 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-d8d91dea0d984fe39fc840b8e0da29c1 |
| Source note | uspto-grants-2016_01 |