p-(Trifluoromethoxy)benzaldehyde → HCID 69082453, compound

HRID 594734Notes

Reaction equation

HRID 594734 reaction equation
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[F:19])[CH2:3][CH:4]([CH3:10])[C:5]([O:7]CC)=O.[F:20][C:21]([F:32])([F:31])[O:22][C:23]1[CH:30]=[CH:29][C:26]([CH:27]=O)=[CH:25][CH:24]=1>>[F:19][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]([O:17][CH3:18])[C:11]=1[CH:2]1[N:1]([CH2:27][C:26]2[CH:29]=[CH:30][C:23]([O:22][C:21]([F:20])([F:31])[F:32])=[CH:24][CH:25]=2)[C:5](=[O:7])[CH:4]([CH3:10])[CH2:3]1

Participants

3

Reactant 2

HCID 69573p-(Trifluoromethoxy)benzaldehydeHCID 69085707Ethyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate

Product 1

HCID 69082453HCID 69082453, compound

Procedure

5-(2-Fluoro-6-methoxyphenyl)-3-methyl-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one was prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate with commercially available 4-(trifluoromethoxy)benzaldehyde. Subsequent purification by FC (heptane/AcOEt=1/1) afforded the compound. LC-MS (conditions A): tR=0.93 min.; [M+H]+: 398.00 g/mol.

Workup

  1. customSubsequent purification by FC (heptane/AcOEt=1/1)
  2. customafforded the compound

Sources & evidence

ORD record
ord-06715fc6cd0c4743a8727c29a4c999a7
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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