Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594734Generated: October 30, 2026

p-(Trifluoromethoxy)benzaldehyde → HCID 69082453, compound

https://huagongshe.com/reaction/594734

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-(Trifluoromethoxy)benzaldehydeHCID 69573—
ReactantEthyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoateHCID 69085707—
ProductHCID 69082453HCID 69082453—

Reaction Steps

5-(2-Fluoro-6-methoxyphenyl)-3-methyl-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one was prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate with commercially available 4-(trifluoromethoxy)benzaldehyde. Subsequent purification by FC (heptane/AcOEt=1/1) afforded the compound. LC-MS (conditions A): tR=0.93 min.; [M+H]+: 398.00 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-06715fc6cd0c4743a8727c29a4c999a7
Source noteuspto-grants-2016_01