2-Ethoxy-6-fluorobenzaldehyde → HCID 86695669, compound

HRID 594752Notes

Reaction equation

HRID 594752 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:13][NH2:14])[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10].[CH2:15]([O:17][C:18]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:19]=1[CH:20]=O)[CH3:16]>>[CH2:15]([O:17][C:18]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:19]=1[CH:20]1[N:14]([CH2:13][C:4]2[CH:5]=[CH:6][C:7]([O:8][C:9]([F:11])([F:12])[F:10])=[C:2]([F:1])[CH:3]=2)[C:7](=[O:8])[CH:2]([F:1])[CH2:3]1)[CH3:16]

Participants

3

Reactant 2

HCID 38158942-Ethoxy-6-fluorobenzaldehydeHCID 177506743-Fluoro-4-(trifluoromethoxy)benzylamine

Product 1

HCID 86695669HCID 86695669, compound

Procedure

Prepared according to the described general procedures 10A2 (GP10A2), 10B (GP10B), 10F (GP10F), and 10I (GP10I) using commercially available (3-fluoro-4-(trifluoromethoxy)phenyl)methanamine and synthesized 2-ethoxy-6-fluorobenzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.93 min.; [M+H]+: 433.92 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-061b1067b6464141b1ffc53bfe142a46
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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