HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Ethoxy-6-fluorobenzaldehyde → rac-(3S*,5S*)-3-chloro-1-(3-chloro-4-(trifluoromethoxy)benzyl)-5-(2-ethoxy-6-fluorophenyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Ethoxy-6-fluorobenzaldehyde | HCID 3815894 | — |
| Reactant | (3-Chloro-4-(trifluoromethoxy)phenyl)methanamine | HCID 53414455 | — |
| Product | rac-(3S*,5S*)-3-chloro-1-(3-chloro-4-(trifluoromethoxy)benzyl)-5-(2-ethoxy-6-fluorophenyl)pyrrolidin-2-one | HCID 86695670 | — |
Reaction Steps
Prepared according to the described general procedures 10A2 (GP10A2), 10B (GP10B), 10F (GP10F), and 10D (GP10D) using commercially available (3-chloro-4-(trifluoromethoxy)phenyl)methanamine and synthesized 2-ethoxy-6-fluorobenzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=1.00 min.; [M+H]+: 465.77 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-50ef022031fc49bfb72294809a6ebcb8 |
| Source note | uspto-grants-2016_01 |