HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 1-(2-Fluorobenzyl)-5-methylpiperidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 1-(2-fluorobenzyl)-5-methylpiperidine-3-carboxylate | HCID 66800957 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | 1-(2-Fluorobenzyl)-5-methylpiperidine-3-carboxylic acid | HCID 66807230 | — |
Reaction Steps
To methyl 1-(2-fluorobenzyl)-5-methylpiperidine-3-carboxylate (0.5 mmol), LiOH (1 mmol) in 2 ml THF/H2O (1:1) was added. The reaction was stirred overnight. The solvent was removed under vacuo. The crude product was progressed to the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242981B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-64cb4bc5b27d4651a16252544ffeffe8 |
| Source note | uspto-grants-2016_01 |