Lithium Hydroxide → 1-(2-Fluorobenzyl)-5-methylpiperidine-3-carboxylic acid

HRID 594939Notes

Reaction equation

HRID 594939 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[CH2:4][N:5]1[CH2:10][CH:9]([CH3:11])[CH2:8][CH:7]([C:12]([O:14]C)=[O:13])[CH2:6]1.[Li+].[OH-]>C1COCC1.O>[F:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[CH2:4][N:5]1[CH2:10][CH:9]([CH3:11])[CH2:8][CH:7]([C:12]([OH:14])=[O:13])[CH2:6]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 66800957Methyl 1-(2-fluorobenzyl)-5-methylpiperidine-3-carboxylate

Product 1

HCID 668072301-(2-Fluorobenzyl)-5-methylpiperidine-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

To methyl 1-(2-fluorobenzyl)-5-methylpiperidine-3-carboxylate (0.5 mmol), LiOH (1 mmol) in 2 ml THF/H2O (1:1) was added. The reaction was stirred overnight. The solvent was removed under vacuo. The crude product was progressed to the next step without further purification.

Workup

  1. customThe solvent was removed under vacuo
  2. customThe crude product was progressed to the next step without further purification

Sources & evidence

ORD record
ord-64cb4bc5b27d4651a16252544ffeffe8
Source dataset
uspto-grants-2016_01
Patent number
US09242981B2

Reaction notes

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