HCID 67112430, compound → HCID 43641970, compound

HRID 595007Notes

Reaction equation

HRID 595007 reaction equation
[CH3:1][NH:2][C:3]([C:5]1[NH:6][CH:7]=[C:8]([N+:10]([O-])=O)[CH:9]=1)=[O:4]>CO>[NH2:10][C:8]1[CH:9]=[C:5]([C:3]([NH:2][CH3:1])=[O:4])[NH:6][CH:7]=1

Participants

3

Reactant 1

HCID 67112430HCID 67112430, compound

Product 1

HCID 43641970HCID 43641970, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of N-methyl-4-nitro-1H-pyrrole-2-carboxamide (75 mg, 0.44 mmol) in methanol was degassed and flushed with N2 (g). 10% Pd on activated carbon was added and the mixture degassed and flushed with N2 (g). H2 (g) was applied and the reaction mixture stirred at rt for 14 h. The resultant mixture was filtered through celite then concentrated in vacuo to afford 4-amino-N-methyl-1H-pyrrole-2-carboxamide as a green solid.

Workup

  1. customflushed with N2 (g)
  2. addition10% Pd on activated carbon was added
  3. customthe mixture degassed
  4. customflushed with N2 (g)
  5. filtrationThe resultant mixture was filtered through celite
  6. concentrationthen concentrated in vacuo

Sources & evidence

ORD record
ord-5e6606411073421c9df5519998f472f7
Source dataset
uspto-grants-2016_01
Patent number
US09242987B2

Reaction notes

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