HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → HCID 86671746, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | HCID 86671745 | HCID 86671745 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86671746 | HCID 86671746 | — |
Reaction Steps
tert-butyl 4-(2,4,5-trifluoro-3-(hydroxymethyl)phenyl)piperazine-1-carboxylate (180 mg, 0.52 mmol) was reacted under the standard conditions with PBr3 in DCM (see Example 189, Step ii) to give tert-butyl 4-(3-(bromomethyl)-2,4,5-trifluorophenyl)piperazine-1-carboxylate (57 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242987B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-40a1ec1a1f4143d498b6226edf1db0f8 |
| Source note | uspto-grants-2016_01 |