HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(5-methyl-7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide → N-[6-(6-Fluoro-pyridine-3-carbonyl)-5-methyl-7-oxo-4,5,6,7-tetrahydro-benzothiazol-2-yl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(5-methyl-7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide | HCID 4644134 | — |
| Reactant | 2-Fluoropyridine-5-carbonyl chloride | HCID 14623602 | — |
| Product | N-[6-(6-Fluoro-pyridine-3-carbonyl)-5-methyl-7-oxo-4,5,6,7-tetrahydro-benzothiazol-2-yl]-acetamide | HCID 86664611 | — |
Reaction Steps
A-16 is prepared via general procedure A1 starting from 2-fluoropyridine-5-carbonyl chloride (4.27 g, 26.8 mmol) and N-(5-methyl-7-oxo-4,5,6,7-tetrahydro-benzothiazol-2-yl)-acetamide (A-06) (5.00 g, 22.3 mmol). Yield: 6.20 g. HPLC-MS: tR=0.93 min, (M+H)+=348.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09243000B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-ce22978455694a388985840d13c040c6 |
| Source note | uspto-grants-2016_01 |