反应详情

温度

80 °C

N-(3-Bromo-5-nitrophenyl)-4-(trifluoromethyl)pyrimidin-2-amine (4.76 g, 13.11 mmol) was dissolved in ethanol (131 ml) and saturated solution of NH4Cl (1 mL) was added followed by Fe (3.66 g, 65.5 mmol). The reaction mixture was stirred at 80° C. for 30 minutes then cooled to room temperature. The solution was filtered through a short pad of silica gel and eluted with EtOAc. The phase were separated, the organics were dried, filtered, concentrated under reduced pressure to afford 5-bromo-N-[4-(trifluoromethyl)pyrimidin-2-yl]benzene-1,3-diamine as a beige powder.

1. temperaturethen cooled to room temperature
2. filtrationThe solution was filtered through a short pad of silica gel
3. washeluted with EtOAc
4. customThe phase were separated
5. customthe organics were dried
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure