2-Aminopropanol → 2,2'-iminodipropanol

HRID 595243Notes

Reaction equation

HRID 595243 reaction equation
[CH3:1][CH:2]([NH2:5])[CH2:3][OH:4].[OH:6][CH2:7][C:8](=O)[CH3:9]>CO.[Pt](=O)=O>[NH:5]([CH:8]([CH3:9])[CH2:7][OH:6])[CH:2]([CH3:1])[CH2:3][OH:4]

Participants

5

Reactant 2

HCID 51262-AminopropanolHCID 8299Hydroxyacetone

Product 1

HCID 407512,2'-iminodipropanol

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

Platinum dioxide (800 mg) was added to a solution of dl-2-amino-1-propanol (100 g) and hydroxyacetone (115 g) in methanol (1100 mL). The reaction mixture was hydrogenated at 60 psi for 20 hours, after which time, the catalyst was filtered off and the solvent was removed under reduced pressure to afford crude 2,2′-iminodipropan-1-ol.

Workup

  1. filtrationafter which time, the catalyst was filtered off
  2. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-13cd052a96f0485eacc5e5df79476fd4
Source dataset
uspto-grants-2016_01
Patent number
US09242984B2

Reaction notes

Loading…