HRID595332
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
CONDITIONS
反应条件
- 温度
- 120 °C
PROCEDURE
实验过程
A solution of 4-[(benzyloxy)methyl]-5-{[4-(3-{[4-(difluoromethyl)pyrimidin-2-yl]amino}-5-methylphenyl)-1H-pyrazol-1-yl]methyl}-1,3-oxazolidin-2-one (100 mg, 0.199 mmol) in TFA (1.0 mL) was stirred and heated at 120° C. in a microwave reactor for 40 minutes. The reaction mixture was concentrated under reduced pressure to afford (5-{[4-(3-{[4-(difluoromethyl)pyrimidin-2-yl]amino}-5-methylphenyl)-1H-pyrazol-1-yl]methyl}-2-oxo-1,3-oxazolidin-4-yl)methyl trifluoroacetate, which was used in the next step without further purification. MS ESI calc'd. for C22H20F5N6O4 [M+H]+ 527. found 527.
WORKUP
后处理
- concentrationThe reaction mixture was concentrated under reduced pressure