反应详情

To a mixture of 2-acetyl-6-amino-5-bromo-N-methylbenzofuran-3-carboxamide (500 mg, 1.61 mmol) and triethylamine (650 mg, 6.43 mmol) in THF (20 mL) was added MsCl (406 mg, 3.54 mmol) dropwise at 0° C. under N2. The mixture was stirred at room temperature for 1 hour. The mixture was quenched with H2O and extracted with EtOAc, and then the combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo to give the crude product. The crude product was dissolved in THF (20 mL) and then a solution of LiOH/H2O (200 mg/6 mL) was added. The mixture was stirred at room temperature for 1 hour, then water was added to the mixture and extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo to give the crude product. The crude product was purified by column chromatography to give compound 2-acetyl-5-bromo-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide (280 mg, yield: 44.8%). 1H-NMR (CDCl3, 400 MHz) δ 9.83 (s, 1H), 8.97 (s, 1H).7.91 (s, 1H), 7.07 (s, 1H), 3.06 (s, 3H), 3.02 (d, J=4.8 Hz, 3H), 2.77 (s, 3H). MS (M+H)+: 389/391.

1. customThe mixture was quenched with H2O
2. extractionextracted with EtOAc
3. washthe combined organic layers were washed with brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo
6. customto give the crude product
7. stirringThe mixture was stirred at room temperature for 1 hour
8. extractionextracted with EtOAc
9. washThe combined organic layers were washed with brine
10. dry with materialdried over Na2SO4
11. concentrationconcentrated in vacuo
12. customto give the crude product
13. customThe crude product was purified by column chromatography