Carbon Dioxide → HCID 178481149, compound

HRID 595607Notes

Reaction equation

HRID 595607 reaction equation
[CH3:1][N:2]1[S:11](=[O:13])(=[O:12])[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[C:4]([OH:14])=[C:3]1[C:15]([NH:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][N:23]=1)=[O:16].[CH2:24]([OH:100])[C@H:25]1[O:30][C@@H:29]2[O:31][C@H:32]3[C@H:37]([OH:38])[C@@H:36]([OH:39])[C@@H:35]([O:40][C@H:41]4[C@H:46]([OH:47])[C@@H:45]([OH:48])[C@@H:44]([O:49][C@H:50]5[C@H:55]([OH:56])[C@@H:54]([OH:57])[C@@H:53]([O:58][C@H:59]6[C@H:64]([OH:65])[C@@H:63]([OH:66])[C@@H:62]([O:67][C@H:68]7[C@H:73]([OH:74])[C@@H:72]([OH:75])[C@@H:71]([O:76][C@H:77]8[C@H:83]([OH:84])[C@@H:82]([OH:85])[C@@H:80]([O:81][C@H:26]1[C@H:27]([OH:99])[C@H:28]2[OH:98])[O:79][C@@H:78]8[CH2:86][OH:87])[O:70][C@@H:69]7[CH2:88][OH:89])[O:61][C@@H:60]6[CH2:90][OH:91])[O:52][C@@H:51]5[CH2:92][OH:93])[O:43][C@@H:42]4[CH2:94][OH:95])[O:34][C@@H:33]3[CH2:96][OH:97].[NH2:101][C@H:102]([C:110]([OH:112])=[O:111])[CH2:103][CH2:104][CH2:105][NH:106][C:107](=[NH:109])[NH2:108].C(=O)=O>O>[CH3:1][N:2]1[S:11](=[O:13])(=[O:12])[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[C:4]([OH:14])=[C:3]1[C:15]([NH:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][N:23]=1)=[O:16].[CH2:90]([OH:91])[C@H:60]1[O:61][C@@H:62]2[O:67][C@H:68]3[C@H:73]([OH:74])[C@@H:72]([OH:75])[C@@H:71]([O:76][C@H:77]4[C@H:83]([OH:84])[C@@H:82]([OH:85])[C@@H:80]([O:81][C@H:26]5[C@H:27]([OH:99])[C@@H:28]([OH:98])[C@@H:29]([O:31][C@H:32]6[C@H:37]([OH:38])[C@@H:36]([OH:39])[C@@H:35]([O:40][C@H:41]7[C@H:46]([OH:47])[C@@H:45]([OH:48])[C@@H:44]([O:49][C@H:50]8[C@H:55]([OH:56])[C@@H:54]([OH:57])[C@@H:53]([O:58][C@H:59]1[C@H:64]([OH:65])[C@H:63]2[OH:66])[O:52][C@@H:51]8[CH2:92][OH:93])[O:43][C@@H:42]7[CH2:94][OH:95])[O:34][C@@H:33]6[CH2:96][OH:97])[O:30][C@@H:25]5[CH2:24][OH:100])[O:79][C@@H:78]4[CH2:86][OH:87])[O:70][C@@H:69]3[CH2:88][OH:89].[NH2:101][C@H:102]([C:110]([OH:112])=[O:111])[CH2:103][CH2:104][CH2:105][NH:106][C:107](=[NH:108])[NH2:109]

Participants

6

Reactant 4

HCID 280Carbon DioxideHCID 444041beta-CyclodextrinHCID 54676228PiroxicamHCID 178418600HCID 178418600, compound

Product 1

HCID 178481149HCID 178481149, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

43 grams of piroxicam, 384 grams of β-cyclodextrin and 25 grams of arginine are introduced into a reactor, along with 61 grams of diffusion agent (water). Carbon dioxide is subsequently introduced into the reactor under a pressure of 15 MPa and under a temperature of 100° C. These operating conditions are maintained for a time of one hour.

Workup

  1. temperatureThese operating conditions are maintained for a time of one hour

Sources & evidence

ORD record
ord-e9d9699e55224eeebaeea191c8077e72
Source dataset
uspto-grants-2016_01
Patent number
US09243076B2

Reaction notes

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