反应详情

温度

0 °C

2-Bromo-1-isopropyl-4-nitrobenzene (XI) (50 g, 0.192 mol, 93.5 GC-% by area), 100 ml of water, ironpowder (40.71 g, 0.718 mol) were heated to 70° C. and hydrochloric acid (193.7 g, 1.647 mol, 31% in water) was added over a period of 2 hours. The mixture was then cooled to 0° C. and the suspension was filtered with suction. The solvent obtained was dried overnight at 50° C. in a vacuum drying oven. 3-Bromo-4-isopropylaniline hydrochloride (48 g, purity: 88.7%, contains: 8.6% of iron, 88.7% of theory) was obtained as a light-brown solid.

1. filtrationthe suspension was filtered with suction
2. customThe solvent obtained
3. customwas dried overnight at 50° C. in a vacuum
4. customdrying oven