HCID 118045314, compound → HCID 118046325, compound

HRID 595896Notes

Reaction equation

HRID 595896 reaction equation
[CH2:1]([O:8][CH2:9][C:10]([C:12]1[N:13]=[CH:14][C:15]([NH2:18])=[N:16][CH:17]=1)=[CH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[Pd]>[CH2:1]([O:8][CH2:9][CH:10]([C:12]1[N:13]=[CH:14][C:15]([NH2:18])=[N:16][CH:17]=1)[CH3:11])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 118045314HCID 118045314, compound

Product 1

HCID 118046325HCID 118046325, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 5-(3-(benzyloxy)prop-1-en-2-yl)pyrazin-2-amine (91 mg, 0.377 mmol) in methanol (3771 μL) was added Pd/C (40.1 mg, 0.377 mmol) at room temperature. The reaction mixture was stirred at room temperature under hydrogen balloon for overnight. The reaction mixture was filtered through Celite, washed with methanol and EtOAc. The crude material was used in next step reaction without purification. LCMS (m/z): 244.2 (MH+), 0.62 min.

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. washwashed with methanol and EtOAc
  3. customThe crude material was used in next step reaction without purification
  4. custom244.2 (MH+), 0.62 min.

Sources & evidence

ORD record
ord-ec6cc320a3ef4a5ab16eee530a1d46b0
Source dataset
uspto-grants-2016_01
Patent number
US09242996B2

Reaction notes

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