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0 °C

To an ice cold solution of N-(2,4-dimethoxybenzyl)-5-(4-methyltetrahydro-2H-pyran-4-yl)pyridin-2-amine (100 mg, 0.29 mmol) in DCM (6 mL) was added 10 mL 30% TFA in DCM solution. The resulting solution was stirred at 0° C. for 15 min. The solvent was removed via vacuum. The resulting residue was redissolved in ethyl acetate, and the organic solution was washed with 1M NaOH, brine, dried over sodium sulfate and concentrated. The residue was purified by flash column chromatography on silicagel (ISCO) eluting with 0-100% ethyl acetate in heptane to give 5-(4-methyltetrahydro-2H-pyran-4-yl)pyridin-2-amine (50 mg, 0.26 mmol, 89% yield) as white color solid. LCMS (m/z): 193 (MH+), 0.35 min.

1. customThe solvent was removed via vacuum
2. dissolutionThe resulting residue was redissolved in ethyl acetate
3. washthe organic solution was washed with 1M NaOH, brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated
6. customThe residue was purified by flash column chromatography on silicagel (ISCO)
7. washeluting with 0-100% ethyl acetate in heptane