Hydrochloric Acid → (S)-2-azido-1-(3-fluoro-5-iodophenyl)ethanamine hydrochloride salt
Reaction equation
OC(C(F)(F)F)=O.NC1C(C2C=CC(C(O)=O)=C(F)C=2)=NC(C2CCOCC2)=CN=1.C1C=NC2N(O)N=NC=2C=1.CCN(C(C)C)C(C)C.[N:50]([CH2:53][C@@H:54]([NH:63]C(=O)OC(C)(C)C)[C:55]1[CH:60]=[C:59]([I:61])[CH:58]=[C:57]([F:62])[CH:56]=1)=[N+:51]=[N-:52].[ClH:71]>CN(C=O)C.O1CCOCC1>[ClH:71].[N:50]([CH2:53][C@H:54]([C:55]1[CH:60]=[C:59]([I:61])[CH:58]=[C:57]([F:62])[CH:56]=1)[NH2:63])=[N+:51]=[N-:52]Participants
Reactant 5
Product 1
Reagents, catalysts & solvents 2
Procedure
4-(3-Amino-6-(tetrahydro-2H-pyran-4-yl)pyrazin-2-yl)-2-fluorobenzoic acid TFA adduct (126 mg, 0.292 mmol) and HOAt (0.060 g, 0.438 mmol) was dissolved in DMF (1 mL) and DIEA (0.156 mL, 0.876 mmol). (S)-2-azido-1-(3-fluoro-5-iodophenyl)ethanamine hydrochloride salt (100 mg, 292 mmol), obtained from the reaction of (S)-tert-butyl (2-azido-1-(3-fluoro-5-iodophenyl)ethyl)carbamate with 4M HCl in dioxane (Step 9 in Scheme 76), was added, followed by EDC (0.090 g, 0.467 mmol). The reaction mixture was stirred at room temperature overnight. The reaction mixture was diluted with EtOAc and water, and the organic layer was washed with water twice and then with saturated Na2CO3. The organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo providing crude (S)-4-(3-amino-6-(tetrahydro-2H-pyran-4-yl)pyrazin-2-yl)-N-(2-azido-1-(3-fluoro-5-iodophenyl)ethyl)-2-fluorobenzamide without further purification.
Sources & evidence
- ORD record
- ord-db05d60599b54d368b0ff5514a378e87
- Source dataset
- uspto-grants-2016_01
- Patent number
- US09242996B2
Reaction notes
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