Ethanolamine → HCID 178433882, compound

HRID 59614Notes

Reaction equation

HRID 59614 reaction equation
[CH2:1]([CH2:3][NH2:4])[OH:2].[CH3:5][C:6]1[CH:7]=[C:8]([N:13]2[C:17](=[O:18])[C:16](=[N:19][NH:20][C:21]3[C:22]([OH:36])=[C:23]([C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([OH:35])=[O:34])[CH:28]=4)[CH:24]=[CH:25][CH:26]=3)[C:15]([CH3:37])=[N:14]2)[CH:9]=[CH:10][C:11]=1[CH3:12]>C(O)C.O1CCCC1>[CH3:12][C:11]1[CH:10]=[CH:9][C:8]([N:13]2[N:14]=[C:15]([CH3:37])/[C:16](=[N:19]/[NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([OH:35])=[O:34])[CH:28]=4)[C:22]=3[OH:36])/[C:17]2=[O:18])=[CH:7][C:6]=1[CH3:5].[CH2:3]([NH2:4])[CH2:1][OH:2]

Participants

5

Reactant 2

HCID 700EthanolamineHCID 178433881HCID 178433881, compound

Product 1

HCID 178433882HCID 178433882, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of ethanolamine (0.9 g) in ethanol (100 mL) was added a solution of 3′-{N′-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]hydrazino}-2′-hydroxybiphenyl-3-carboxylic acid (3 g), prepared as in Example 4, in tetrahydrofuran (40 mL) at about room temperature over about 30 to 40 minutes and stirred for about 3 hours at about room temperature. The mixture was filtered, washed with ethanol (25 mL) and dried in an oven at about 55° C. to about 60° C. for about 12 hours. Yield: 3.7 g

Workup

  1. filtrationThe mixture was filtered
  2. washwashed with ethanol (25 mL)
  3. customdried in an oven at about 55° C. to about 60° C. for about 12 hours

Sources & evidence

ORD record
ord-2bf51df7cd0e4194bf1cddb482401049
Source dataset
uspto-grants-2016_09
Patent number
US09440927B2

Reaction notes

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