Formamide → 4H-Pyrrolo(3,4-d)pyrimidin-4-one, 1,6-dihydro-5-methyl-7-phenyl-

HRID 596145Notes

Reaction equation

HRID 596145 reaction equation
Cl.[NH2:2][C:3]1[C:7]([C:8]([O:10]CC)=O)=[C:6]([CH3:13])[NH:5][C:4]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH:20]([NH2:22])=O>>[CH3:13][C:6]1[NH:5][C:4]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[C:3]2[C:7]=1[C:8](=[O:10])[NH:22][CH:20]=[N:2]2

Participants

3

Reactant 2

HCID 713FormamideHCID 12339474HCID 12339474, compound

Product 1

HCID 1354173944H-Pyrrolo(3,4-d)pyrimidin-4-one, 1,6-dihydro-5-methyl-7-phenyl-

Procedure

A mixture of 3 g. (0.0107 mole) of 3-amino-4-carbethoxy-5-methyl-2-phenyl-pyrrole hydrochloride and 20 ml. (0.242 mole) of formamide are cautiously heated at 160° C for 16 hours. Upon cooling to room temperature the title compound precipitates as a solid substance, which is recovered by filtration and washed with water.

Workup

  1. additionA mixture of 3 g

Sources & evidence

ORD record
ord-44b489f31755410fb960355643a3f0f4
Source dataset
uspto-grants-1977_03
Patent number
US04010159

Reaction notes

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