Formamide → 4H-Pyrrolo(3,4-d)pyrimidin-4-one, 1,6-dihydro-5-methyl-7-phenyl-

Participants

Reaction Steps

A mixture of 3 g. (0.0107 mole) of 3-amino-4-carbethoxy-5-methyl-2-phenyl-pyrrole hydrochloride and 20 ml. (0.242 mole) of formamide are cautiously heated at 160° C for 16 hours. Upon cooling to room temperature the title compound precipitates as a solid substance, which is recovered by filtration and washed with water.

Provenance & Evidence