Hydrogen Bromide → HCID 12353616, compound

HRID 596245Notes

Reaction equation

HRID 596245 reaction equation
Cl.[NH2:2][CH:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:15]C)[C:9]=2[O:13]C)[C:4]1=[O:17].[BrH:18]>>[BrH:18].[NH2:2][CH:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([OH:15])[C:9]=2[OH:13])[C:4]1=[O:17]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 12353614HCID 12353614, compound

Product 1

HCID 12353616HCID 12353616, compound

Procedure

30 parts of 2-amino-5,6-dimethoxy-3,4-dihydro-1(2H)-naphthalenone hydrochloride is subjected to boiling reflux in 500 volume parts of a 47 % aqueous solution of hydrogen bromide for 3 hours and, then, concentrated to dryness under reduced pressure. The residue is dissolved in methanol, followed by the addition of ethyl acetate, whereupon crystals separate. Filtrative recovery yields 31 parts of 2-amino-5,6-dihydroxy-3,4-dihydro-1(2H)-naphthalenone hydrobromide.

Workup

  1. concentrationconcentrated to dryness under reduced pressure
  2. dissolutionThe residue is dissolved in methanol
  3. additionfollowed by the addition of ethyl acetate, whereupon crystals
  4. customseparate

Sources & evidence

ORD record
ord-7606176278314e8099dbaa17fb44fdcc
Source dataset
uspto-grants-1977_03
Patent number
US04010202

Reaction notes

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