Ethyl Acetate → HCID 12391009, compound

HRID 596261Notes

Reaction equation

HRID 596261 reaction equation
Br.[NH2:2][CH:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([OH:14])[C:9]=2[OH:13])[CH:4]1[OH:15].[OH:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C:24](=O)[CH3:25])=[CH:19][CH:18]=1.[C:27]([O:30]CC)(=[O:29])[CH3:28]>C(O)C>[C:9]([OH:13])(=[O:16])/[CH:10]=[CH:28]/[C:27]([OH:30])=[O:29].[OH:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH:24]([NH:2][CH:3]2[CH2:12][CH2:11][C:10]3[C:5](=[CH:6][CH:7]=[C:8]([OH:14])[C:9]=3[OH:13])[CH:4]2[OH:15])[CH3:25])=[CH:19][CH:18]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 70192744-HydroxyphenylacetoneHCID 12353618HCID 12353618, compound

Product 1

HCID 12391009HCID 12391009, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner similar to that of Example 9, 4 parts of 2-amino-1,5,6-trihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide is reacted with 20 parts of 4-hydroxyphenylacetone. The reaction product is dissolved in ethanol and ethyl acetate is added to the solution. The procedure yields 2 parts of 2-(4-hydroxy-α-methylphenethylamino)-1,5,6-trihydroxy-1,2,3,4-tetrahydronaphthalene fumarate as colorless crystals melting at 137°-141° C.

Sources & evidence

ORD record
ord-d742206bbbf3404da8aef94c16368977
Source dataset
uspto-grants-1977_03
Patent number
US04010202

Reaction notes

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