Hydrofluoric Acid → HCID 12251281, compound

HRID 596279Notes

Reaction equation

HRID 596279 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:4][CH:3]1CCC(O)=O.F>>[C:5]12([CH2:4][CH2:3][C:2](=[O:1])[CH2:7][CH2:6]1)[C:8]1[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2](=[O:1])[CH2:3][CH2:4]2

Participants

3

Reactant 2

HCID 14917Hydrofluoric AcidHCID 21433513HCID 21433513, compound

Product 1

HCID 12251281HCID 12251281, compound

Procedure

A 4-oxo-1-phenylcyclohexane-3-propionic acid (i) prepared in step (6) or (6') is cyclized, e.g., by allowing it to stand at room temperature for from about 15 to about 80 hours with liquid hydrogen fluoride, to yield a corresponding spiro[cyclohexane-1,1'(2'H)-naphthalene]-4,4'(3'H)-dione (o).

Sources & evidence

ORD record
ord-8407afa4053b49758513b4ada417240c
Source dataset
uspto-grants-1977_03
Patent number
US04010201

Reaction notes

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