Sodium borohydride → HCID 12251285, compound

HRID 596280Notes

Reaction equation

HRID 596280 reaction equation
[C:1]12([CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH2:11]1)[C:10]1[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=1)[CH2:4][CH2:3][CH2:2]2.[BH4-].[Na+]>C(O)C>[C:1]12([CH2:11][CH2:12][CH:13]([OH:16])[CH2:14][CH2:15]1)[C:10]1[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=1)[CH2:4][CH2:3][CH2:2]2

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 12251284HCID 12251284, compound

Product 1

HCID 12251285HCID 12251285, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 3',4'-dihydrospiro[cyclohexane-1,1'(2'H)-naphthalen]-4-one (r) produced in step (10) has its 4-keto function reduced, e.g., by mixing said compound in a solvent such as ethanol with sodium borohydride at moderate (room) temperature for from about 3 to about 8 hours, to produce a corresponding 3',4'-dihydrospiro[cyclohexane-1,1'(2H)naphthalen]-4-ol (s).

Workup

  1. additione.g., by mixing
  2. customfor from about 3 to about 8 hours

Sources & evidence

ORD record
ord-4040aa4959ff4e4f84c95bd5a0c2c795
Source dataset
uspto-grants-1977_03
Patent number
US04010201

Reaction notes

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