2-Methyl-2-{4-[2-methoxy-5-chloro-benzamido-methyl]-biphenyl-4'-oxy}-propionate → 2-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'oxy}-propionic acid

HRID 596334Notes

Reaction equation

HRID 596334 reaction equation
[CH3:1][C:2]([O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][NH:21][C:22](=[O:32])[C:23]3[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:24]=3[O:30][CH3:31])=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)([CH3:6])[C:3]([O-:5])=[O:4]>[OH-].[K+].O1CCOCC1>[CH3:6][C:2]([O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][NH:21][C:22](=[O:32])[C:23]3[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:24]=3[O:30][CH3:31])=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)([CH3:1])[C:3]([OH:5])=[O:4]

Participants

4

Reactant 1

HCID 214519262-Methyl-2-{4-[2-methoxy-5-chloro-benzamido-methyl]-biphenyl-4'-oxy}-propionate

Product 1

HCID 214185292-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'oxy}-propionic acidYield 72%

Reagents, catalysts & solvents 2

HCID 14797Potassium HydroxideSolventHCID 312751,4-DioxaneSolvent

Procedure

2-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'-oxy}-propionic acid was prepared by alkaline hydrolysis of 2-methyl-2-{4-[2-methoxy-5-chloro-benzamido-methyl]-biphenyl-4'-oxy}-propionate in 1 N potassium hydroxide and dioxane (1:5) at room temperature. Yield: 72% of theory; m.p. 104° C

Sources & evidence

ORD record
ord-53871a992df04cb1918cc8c303e85b7b
Source dataset
uspto-grants-1977_03
Patent number
US04010279

Reaction notes

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