HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-2-{4-[2-methoxy-5-chloro-benzamido-methyl]-biphenyl-4'-oxy}-propionate → 2-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'oxy}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-2-{4-[2-methoxy-5-chloro-benzamido-methyl]-biphenyl-4'-oxy}-propionate | HCID 21451926 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'oxy}-propionic acid | HCID 21418529 | 72% |
Reaction Steps
2-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'-oxy}-propionic acid was prepared by alkaline hydrolysis of 2-methyl-2-{4-[2-methoxy-5-chloro-benzamido-methyl]-biphenyl-4'-oxy}-propionate in 1 N potassium hydroxide and dioxane (1:5) at room temperature. Yield: 72% of theory; m.p. 104° C
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04010279 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-53871a992df04cb1918cc8c303e85b7b |
| Source note | uspto-grants-1977_03 |