2-Hydroxyacetohydrazide → HCID 19865793, compound

HRID 596354Notes

Reaction equation

HRID 596354 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=S)[CH2:10][N:9]=[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:7]=2[CH:21]=1.[OH:24][CH2:25][C:26]([NH:28][NH2:29])=O>C(O)CCC>[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:26]([CH2:25][OH:24])=[N:28][N:29]=[C:11]3[CH2:10][N:9]=[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:7]=2[CH:21]=1

Participants

4

Reactant 2

HCID 3505362-HydroxyacetohydrazideHCID 19865818HCID 19865818, compound

Product 1

HCID 19865793HCID 19865793, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

In the manner given in Example 1, a solution of 1,3-dihydro-7-trifluoromethyl-5-(o-chlorophenyl)-2H-1,4-benzodiazepine-2-thione and hydroxyacetic acid hydrazide in n-butyl alcohol is refluxed to give 8-trifluoromethyl-1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine. Preparation 5 1-(Hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Sources & evidence

ORD record
ord-bea704b51bad49259827afd5f49018a8
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

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