Bromoacetyl bromide → 8-nitro-1(bromomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine

Participants

Role	Name	HCID	Charge
Reactant	Bromoacetyl bromide	HCID 61147	—
Reactant	Sodium Acetate	HCID 517045	—
Reactant	7-nitro-2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine	HCID 20291856	—
Product	8-nitro-1(bromomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine	HCID 20291832	—

Reaction Steps

In the manner given in Preparation 10, 7 -nitro-5(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl hydrazine is reacted with bromoacetyl bromide and after 1.5 hours with sodium acetate, then refluxed to give 8-nitro-1(bromomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine. Preparation 15 1-(Chloromethyl)-7-(trifluoromethyl)-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04010177
Source dataset	uspto-grants-1977_03
ORD ID	ord-c93ba8c0dfd54863b34ca9a4668b6d4f
Source note	uspto-grants-1977_03