Chloroacetyl chloride → HCID 21450834, compound

HRID 596362Notes

Reaction equation

HRID 596362 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[C:8]2[C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])=[N:10][CH2:11][C:12]([NH:14][NH2:15])=[N:13][C:7]=2[CH:6]=[CH:5][CH:4]=1.[Cl:25][CH2:26][C:27](Cl)=O.C([O-])(=O)C.[Na+]>>[Cl:25][CH2:26][C:27]1[N:13]2[C:7]3[CH:6]=[CH:5][CH:4]=[C:3]([C:2]([F:1])([F:23])[F:24])[C:8]=3[C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])=[N:10][CH2:11][C:12]2=[N:14][N:15]=1

Participants

4

Reactant 3

HCID 6577Chloroacetyl chlorideHCID 517045Sodium AcetateHCID 21450815HCID 21450815, compound

Product 1

HCID 21450834HCID 21450834, compound

Procedure

In the manner given in Preparation 10, 6-(trifluoromethyl)-5-(o-fluorophenyl)-3H-1,4-benzodiazepin-2-yl hydrazine is reacted with chloroacetyl chloride and after 1.5 hours with sodium acetate, then refluxed to give 1-(chloromethyl)-7-(trifluoromethyl)-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Workup

  1. temperaturerefluxed

Sources & evidence

ORD record
ord-c5a0069cabe949d3944bcff57b23190f
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

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