HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → Ethyl Acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 7-Hydroxy-8-methoxycoumarin | HCID 5316302 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl Acetate | HCID 8857 | 90% |
| Product | HCID 118376976 | HCID 118376976 | — |
Reaction Steps
1.8 g of hydrangetin (0.01 mole) is acetylated with 1.35 g of 2-chloroacetyl chloride (0.012 mole) by heating at 80° C. in dimethylformamide in the presence of sodium carbonate. After vacuum filtration and evaporation, 7-(2′-chloroacetyloxy)-8-methoxycoumarin (compound A) is isolated by crystallization in ethyl acetate (yield 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440940B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-0dc208a260cf4cd0b83ae056c3399b7e |
| Source note | uspto-grants-2016_09 |