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HRID59638

反应详情

EQUATION

反应方程式

HRID 59638 的结构方程式

REACTANTS

反应物

3
结构：O=C(Cl)CCl
HCID6577

Chloroacetyl chloride

C2H2Cl2O

结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：COc1c(O)ccc2ccc(=O)oc12
HCID5316302

2H-1-Benzopyran-2-one, 7-hydroxy-8-methoxy-

C10H8O4

PRODUCTS

生成物

2
结构：CCOC(C)=O
HCID8857

Ethyl acetate

C4H8O2

收率 90%
结构：COc1c(OC(=O)CCl)ccc2ccc(=O)oc12
HCID118376976

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

1.8 g of hydrangetin (0.01 mole) is acetylated with 1.35 g of 2-chloroacetyl chloride (0.012 mole) by heating at 80° C. in dimethylformamide in the presence of sodium carbonate. After vacuum filtration and evaporation, 7-(2′-chloroacetyloxy)-8-methoxycoumarin (compound A) is isolated by crystallization in ethyl acetate (yield 90%).

WORKUP

后处理

  1. filtrationAfter vacuum filtration and evaporation