Potassium Iodide → HCID 68120042, compound

HRID 596382Notes

Reaction equation

HRID 596382 reaction equation
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH2:16]Cl)=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:7]=2[CH:25]=1.[I-].[K+].[CH3:30][CH:31]=[CH:32][CH2:33][NH2:34]>O1CCCC1>[F:26][C:2]([F:27])([F:1])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH2:16][NH:34][CH2:33][CH2:32][CH:31]=[CH2:30])=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:7]=2[CH:25]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 304472-Buten-1-amineHCID 213307808-(trifluoromethyl)-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Product 1

HCID 68120042HCID 68120042, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Preparation 39, 8-(trifluoromethyl)-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine, potassium iodide and methylallylamine in tetrahydrofuran are reacted to give 8-(trifluoromethyl)-1-[(allylmethylamino)methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine. Preparation 44 8-Chloro-1-[(allylpropylamino)methyl]-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-1f091142e36f43a785ff95916089de5d
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

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