Potassium Iodide → HCID 68120141, compound

HRID 596385Notes

Reaction equation

HRID 596385 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15]Cl)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])[C:6]=2[CH:24]=1.[I-].[K+].[CH2:27]([CH:29]=[CH:30][CH2:31][NH2:32])[CH3:28]>O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][NH:32][CH2:31][CH2:30][CH2:29][CH:27]=[CH2:28])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])[C:6]=2[CH:24]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 21437280HCID 21437280, compoundHCID 53415115HCID 53415115, compound

Product 1

HCID 68120141HCID 68120141, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Preparation 39, 8-fluoro-1-(chloromethyl)-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine, potassium iodide and ethylallylamine in tetrahydrofuran are reacted to give 8-fluoro-1-[(allylethylamino)methyl]-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine. Preparation 47 9-(Trifluoromethyl)-1-[(allylmethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-8d463dd6124440529bd0f95350b7c301
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

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