Allylamine → HCID 21450935, compound

HRID 596400Notes

Reaction equation

HRID 596400 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:26])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[C:19]([CH2:20][N:21]([CH3:23])[CH3:22])=[N:18][N:17]=[C:16]1[CH2:24]O.CS(Cl)(=O)=O.[CH2:32]([NH2:35])[CH:33]=[CH2:34]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:26])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[C:19]([CH2:20][N:21]([CH3:23])[CH3:22])=[N:18][N:17]=[C:16]1[CH2:24][NH:35][CH2:32][CH:33]=[CH2:34]

Participants

4

Reactant 3

HCID 7853AllylamineHCID 31297Methanesulfonyl chlorideHCID 21450855HCID 21450855, compound

Product 1

HCID 21450935HCID 21450935, compound

Procedure

In the manner given in Example 47, 2'-chloro-2-[3-(hydroxymethyl)-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone is treated first with methanesulfonyl chloride followed by allylamine to give 2'-chloro-2-[3-[(allylamino)methyl]-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record
ord-b6f943ecc1644c46a601a6ee073a25df
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

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