Ethanesulfonyl chloride → HCID 21450819, compound

HRID 596402Notes

Reaction equation

HRID 596402 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:27])[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[C:20]([CH2:21][N:22]([CH3:24])[CH3:23])=[N:19][N:18]=[C:17]1[CH2:25]O.C(S(Cl)(=O)=O)C.[CH:34]1([CH2:37][NH2:38])[CH2:36][CH2:35]1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:27])[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[C:20]([CH2:21][N:22]([CH3:24])[CH3:23])=[N:19][N:18]=[C:17]1[CH2:25][NH:38][CH2:37][CH:34]1[CH2:36][CH2:35]1

Participants

4

Reactant 3

HCID 11667Ethanesulfonyl chlorideHCID 75646CyclopropanemethanamineHCID 21450871HCID 21450871, compound

Product 1

HCID 21450819HCID 21450819, compound

Procedure

In the manner given in Example 47, 2',5-dichloro-2-[3-(hydroxymethyl)-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone is treated first with ethanesulfonyl chloride followed by (cyclopropylmethyl)amine, to give 2',5-dichloro-2-[3-[[(cyclopropylmethyl)amino]methyl]-5-[(dimethylamino)-methyl]-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record
ord-207b8d5ae514491ba4c9fc268900f1ee
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

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