Methanesulfonyl chloride → HCID 21450903, compound

HRID 596405Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:29])[C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:11][C:10]=1[N:18]1[C:22]([CH2:23][N:24]([CH3:26])[CH3:25])=[N:21][N:20]=[C:19]1[CH2:27]O.CS(Cl)(=O)=O.[CH2:35]([NH2:38])[C:36]#[CH:37]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:29])[C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:11][C:10]=1[N:18]1[C:22]([CH2:23][N:24]([CH3:26])[CH3:25])=[N:21][N:20]=[C:19]1[CH2:27][NH:38][CH2:35][C:36]#[CH:37]

Participants

Reactant 3

HCID 31297Methanesulfonyl chloride

HCID 239041Propargylamine

HCID 21450961HCID 21450961, compound

Product 1

HCID 21450903HCID 21450903, compound

Procedure

In the manner given in Example 47, 2'-chloro-5-nitro-2-[3-(hydroxymethyl)-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone is treated first with methanesulfonyl chloride followed by propargylamine, to give 2'-chloro-5-nitro-2-[3-[[(2-propynyl)amino]methyl]-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record: ord-01554f2260874283870fcc1abb25fd1c
Source dataset: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04010177

Reaction notes

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