Sulfuric Acid → HCID 178514941, compound

HRID 596437Notes

Reaction equation

HRID 596437 reaction equation
[OH:1][C:2]1[N:3]=[C:4]([C:12]2[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=2[C:14](O)=[O:15])[C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.OS(O)(=O)=O>O>[O:15]=[C:14]1[C:13]2[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=2[C:4]2[N:3]=[C:2]([OH:1])[CH:11]=[C:10]3[CH:9]=[CH:8][CH:7]=[C:6]1[C:5]=23

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 178524290HCID 178524290, compound

Product 1

HCID 178514941HCID 178514941, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

103 g. of o-(3-hydroxy-1-isoquinolinyl)-benzoic acid were dispersed in 310 ml. of 96% H2SO4. This dispersion was then heated to 130° C. and kept under stirring at that temperature for 1 hour. The reaction mass was then cooled to about 90° C. and was then carefully poured into about 20 liters of hot water at 90°-95° C. The reaction mass was then stirred for 1 hour while leaving it to cool down.

Workup

  1. temperatureThe reaction mass was then cooled to about 90° C.
  2. stirringThe reaction mass was then stirred for 1 hour
  3. customwhile leaving it
  4. temperatureto cool down

Sources & evidence

ORD record
ord-0684692f421f45a980573a597d2e8ee7
Source dataset
uspto-grants-1977_03
Patent number
US04011227

Reaction notes

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