反应详情

温度

80 °C

3-Methyl-5,6,7,8-tetrahydroquinoline (50 g.) was dissolved in glacial acetic acid (180 ml.) and the solution treated with 30% hydrogen peroxide (70 ml.) and heated at 80° C for 20 hours. The solvent was removed in vacuo and the residual oil diluted with water (25 ml.) and re-evaporated. The resulting oil was dissolved in chloroform (100 ml.), washed with aqueous sodium carbonate (2 × 25 ml.), saturated brine (2 × 25 ml.), dried (MgSO4) and the solvent removed in vacuo to give 3-Methyl-5,6,7,8-tetrahydroquinoline-1-oxide (60 g.) as a pale yellow solid which was used without purification.

1. customThe solvent was removed in vacuo
2. additionthe residual oil diluted with water (25 ml.)
3. customre-evaporated
4. dissolutionThe resulting oil was dissolved in chloroform (100 ml.)
5. washwashed with aqueous sodium carbonate (2 × 25 ml.), saturated brine (2 × 25 ml.)
6. dry with materialdried (MgSO4)
7. customthe solvent removed in vacuo