反应详情

A mixture of ethyl 7,8-dimethoxypyrimido[4,5-b]quinolin-4(3H)-one-2-carboxylate (300 mg., 0.90 mM) and ethanol (75 ml.) saturated with anhydrous monomethylamine is heated at 95° C. for 24 hours in a stainless steel bomb. The bomb and contents are cooled, the contents removed and concentrated to dryness under reduced pressure. The residue is recrystallized from chloroform/ethyl acetate to give 250 mg. (88%) of product, m.p. 334° C. (dec.).

1. temperatureThe bomb and contents are cooled
2. customthe contents removed
3. concentrationconcentrated to dryness under reduced pressure
4. customThe residue is recrystallized from chloroform/ethyl acetate
5. customto give 250 mg