反应详情

To a solution of 5.0 g. of 3,4-ethylenedioxybenzoic acid methyl ester in 5.0 mls. of glacial acetic acid is added dropwise 5.0 mls. of 70% nitric acid at 50°-60° C. After addition the reaction mixture is kept at 55° C. for one hour, then cooled and 50 mls. of ice water added. The resulting precipitate is recovered by filtering, water washed and dried to obtain 6-nitro-3,4-ethylenedioxybenzoic acid methyl ester, m.p. 115°-118° C.

1. customat 50°-60° C
2. additionAfter addition the reaction mixture
3. temperaturecooled
4. customThe resulting precipitate is recovered
5. filtrationby filtering
6. washwater washed
7. customdried