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Nitric Acid → Methyl 7-Nitro-1,4-benzodioxane-6-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | Methyl 2,3-dihydro-1,4-benzodioxine-6-carboxylate | HCID 3802178 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | Methyl 7-Nitro-1,4-benzodioxane-6-carboxylate | HCID 10537941 | — |
反応手順
To a solution of 5.0 g. of 3,4-ethylenedioxybenzoic acid methyl ester in 5.0 mls. of glacial acetic acid is added dropwise 5.0 mls. of 70% nitric acid at 50°-60° C. After addition the reaction mixture is kept at 55° C. for one hour, then cooled and 50 mls. of ice water added. The resulting precipitate is recovered by filtering, water washed and dried to obtain 6-nitro-3,4-ethylenedioxybenzoic acid methyl ester, m.p. 115°-118° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04011323 |
| 出典データセット | uspto-grants-1977_03 |
| ORD ID | ord-5a4af898b3bc4654963153c4509d354d |
| 出典メモ | uspto-grants-1977_03 |